Name of the drug Revia
Active substance Naltrexone
Packaging 90 tablet
60 tablet
30 tablet
20 tablet
10 tablet
Dosage 50 mg
Price from $ 5.50 for pill
Purchase Revia Over-the-Counter

ReVia - Naltrexone

How does this drug work? What does he do for me?

Naltrexone belongs to a group of drugs known as pure opioid competitors. It is used to help people who were previously dependent on addictive drugs (such as alcohol or opiates like methadone or heroin) to remain dependent.

OPPO drugs (also called opioids) and opioids that make up a natural part of the body affect a specific part of the brain called the opioid receptor. Naltrexone works with these opiate receptors to block the effects of opiates and opiates on the body itself. This is believed to help prevent individuals from returning to the use of these substances.

This medication is used in conjunction with other forms of treatment such as psychological counseling and social support.

Your physician may have suggested this medication for other conditions other than those listed in these drug information articles. Also, some forms of this medication may not be used for all the conditions discussed here. If you have not spoken with your doctor or are unsure why you are taking this medication, talk to your doctor. Do not take this medication without talking to your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you. Taking this medicine may be harmful to people if their doctor has not prescribed it.

In what form (forms) is this medicine released?

Each yellow, capsule-shaped tablet coated with a thin film, inscribed on one side with "R11" and "50" and a bite, contains 50 mg of HCl naltrexone. Nonmedicinal ingredients: silicon dioxide, cubedone, lactose monohydrate, magnesium stear, microcrystalline cellulose, light yellow opadry YS-1-6378-G.

How should I use this drug?

The dosage of this drug depends on the type of dependency being treated and whether the drug is administered under supervision.

For treatment of alcohol dependence, the usual recommended dose is 50 mg once daily.

For treatment of opioid dependence (e.g., methadone or heroin addiction), doses vary, but the usual initial dose is 25 mg once daily and increases slowly with the most appropriate dose.

Your physician will determine the dose and dosing program for your individual condition. It is important that you take this medication as your physician has prescribed you.

The physician may request a urine sample prior to starting treatment with this medication to ensure that the patient has not used drugs (opioid medications) in the past 7-10 days. Do not take this medication if there is any possibility of opiate use in the past 7-10 days. If there is any doubt about opiate use, your doctor may ask you to do a Narcan challenge test to make sure your body has not received opiates before taking this medication.

If you skip a dose, take it as soon as possible and continue with your normal schedule. If it is almost time for the next dose, skip the omitted dose and continue with your normal dosage program. Do not take a double dose to make up for the omitted dose. Contact your doctor or pharmacist if you are unsure what to do after dose expiration.

Keep this medication at room temperature, protected from light and moisture, and away from children.

Do not throw the medication down a sewer (e.g., sink or toilet) or into domestic waste. Ask your pharmacist how to refuse medication you no longer need or that has expired.

Who should not take this medication?

Do not take naltrexone if

  • You are allergic to naltrexone or any of the drug's ingredients
  • You are dependent on opiates, including if you have received an opiate fighter (e.g. methadone)
  • You are experiencing opiate deprivation syndrome
  • You take opiate analgesics (e.g., drugs such as oxycodone or codeine)
  • You have a positive urine test for opiates
  • You have acute hepatitis or liver insufficiency
  • You have failed a Narcan challenge (used to determine if you have used opiates)

What side effects are possible with this drug?

Many medications can cause side effects. A side effect is an unwanted reaction to a drug when taken at normal doses. Side effects may be mild or severe, temporary or permanent.

The side effects listed below do not present for everyone taking this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.

The following side effects have been reported by at least 1% of people taking this medication. You can cope with many of these side effects and some may disappear on their own over time.

If you exhibit any of these side effects and find them serious or annoying, contact your physician. Your pharmacist may be able to advise you on the management of undesirable behaviors.

  • Abdominal pain or cramps
  • Anxiety
  • Chills
  • Constipation
  • Reduced libido
  • Slow ejaculation
  • Difficulty sleeping
  • Drowsiness
  • Dry mouth
  • Fatigue
  • Sensation of depression
  • Headache
  • Increased energy
  • Increased thirst
  • Indigestion
  • Irritability
  • Joint and muscle aches
  • Decreased appetite
  • Low energy
  • motion sickness
  • nervousness
  • vomiting or diarrhea
  • changes in body weight.

Most of the following side effects occur infrequently, but can lead to serious problems if you do not seek medical attention.

If you experience any of the following side effects, contact your physician as soon as possible

  • dizziness
  • Increased blood pressure
  • Signs of liver problems (nausea, vomiting, diarrhea, loss of appetite, weight loss, yellow skin or white eyes, dark urine, pale stools)
  • Increased blood pressure
  • Skin rash
  • Symptoms of a cold (e.g., nasal congestion, runny nose, sneezing, sore throat, excessive ph, cough, supper)
  • Symptoms of depression (e.g., low energy, feelings of worthlessness, guilt, weakness or hopelessness)
  • Medication deprivation symptoms (tears, nausea, abdominal cramps, concerns, bone or joint pain, muscle aches, nasal irritation)

Discontinue taking the medication and seek medical assistance immediately if any of the following occur

  • Suicide attempt or thoughts of suicide
  • Quick or irregular heartbeats
  • Signs of an allergic reaction (difficulty breathing, ur measles, skin rash, facial swelling, throat swelling, etc.)

Some people may exhibit different side effects than those mentioned If you notice any worrisome symptoms while taking this medication, contact your doctor.

Are there any other precautions or warnings with this medication?

Before taking the medication, tell your doctor about any medical conditions or allergies you may have, any medications you are taking, and any other important information about your health, such as pregnancy or breastfeeding. These factors may affect how you need to take this medication.

Random swallows: If you are a drug addict and accidentally swallow this medication, you may have severe deprivation symptoms such as confusion, nausea, tremors, sweating, anxiety, visual illusions, vomiting, and diarrhea. Do not give this drug to others, especially those who are addicted to opiates.

Alcohol: Do not drink alcohol when taking this medication. This is because it can harm the liver.

Interference with related opiates: Because this medication works by blocking the opiate effect, it may affect other opiates, including some cough and cold medicines, antinucleotics, and analgesics. Consult your physician or pharmacist for alternatives that do not contain opiates.

Renal function: Your doctor may reduce the dose of this medication if your kidney function declines. Your doctor may also ask you to have regular kidney tests while you are taking this medication.

Liver function: Naltrexone can cause liver damage. If your liver function is impaired, your doctor may reduce the dose of this medication. Your doctor may ask you to have regular liver tests while taking this medication. Contact your doctor immediately if you have any liver problems such as fatigue, feeling sick, loss of appetite, nausea, yellow skin or white eyes, dark urine, pale stools, abdominal pain, swelling or itchy skin.

Overdose: If you accidentally overdose on this medication, seek medical assistance immediately.

Suicide: People with substance abuse problems are at increased risk for suicide. Naltrexone use does not reduce this risk.

Opioid medications: if you attempt to overcome the inhibitory effects of naltrexone by taking opiates, this can lead to breathing difficulties and death. Do not take narcotics when you are taking this drug. In addition, you may be more sensitive to lower doses of opiate after naltrexone treatment. You may need a lower dose than the dose you acquired to achieve the same results.

Alcohol Dependence Treatment: The use of naltrexone for the treatment of alcohol dependence has been studied with only a once-daily dosing regimen of 50 mg for up to 12 weeks. The efficacy of naltrexone beyond 12 weeks in this population is unknown.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your physician immediately.

Breastfeeding: It is not known if naltrexone passes into breast milk. If you are a mother who is breastfeeding and taking this medication, it could affect your baby. Talk to your doctor about whether you should continue breastfeeding.

CHILDREN: The safety and effectiveness of the use of this medication has not been documented for children under the age of 18.

What other drugs can interact with this medication?

There may be interactions between naltrexone and any of the following

  • disulfiram
  • Glenbryde
  • Drugs containing opiates (e.g., codeine, morphine, oxycodone)
  • Nabilone
  • Naligolide

If you are taking any of these medications, consult your doctor or pharmacist. Depending on your particular situation, your doctor may want you to

  • To stop taking one of the medications,
  • Replace one of the medications with another medication, and
  • Change the way you take one or both medications, or
  • Leave them all in place.

An interaction between two medications does not mean you have to stop taking one of them. Talk to your doctor about how you are being treated or how the drug interaction should be addressed.

Medications other than those listed above may interact with this medication. Inform your physician or prescriber of all prescription, non-prescription (non-prescription) and herbal medications you are taking. Also notify any supplements received. Caffeine, alcohol, tobacco nicotine, or street drugs can affect the action of many medications, so you must inform your prescription if you use them.

Low-Dose Naltrexone for Fibromyalgia and ME/CFS

Adrienne Dellwo is a veteran journalist diagnosed with fibromyalgia and has written extensively on the subject.

David Ozeri, MD, is a board-certified rheumatologist from Tel Aviv, Israel, specializing in arthritis, autoimmune diseases, and biologic therapies.

Low-dose naltrexone therapy helps reduce pain and fatigue associated with fibromyalgia and chronic fatigue syndrome.

Naltrexone is a drug that has been used for over 30 years to treat alcoholism and opioid use disorders. More recently, researchers have discovered that low doses of naltrexone (about one-thirtieth the normal dose) may be helpful for other conditions as well.

This article reviews the benefits and uses of low-dose naltrexone as it relates to fibromyalgia and chronic fatigue syndrome. It also discusses the side effects of LDN therapy and what to avoid when taking naltrexone.

How does low-dose naltrexone work?

Naltrexone at the usual dose of 50 to 100 milligrams (mg) blocks the effects of opioid analgesics and alcohol. It works by binding to opioid and endorphin receptors, preventing the adhesion of pleasant molecules found in alcohol and opioids.

Researchers are not entirely sure how low doses of naltrexone work to relieve fibromyalgia, chronic fatigue syndrome, and possibly other conditions. The recommended route is as follows

  • LDN blocks certain proteins that cause symptoms of fibromyalgia and chronic fatigue syndrome in the nervous system, which is the body's primary control and communication system
  • LDN acts as an anti-inflammatory agent, reducing inflammation and swelling of the nervous system
  • LDN helps maintain the balance of the immune system. That is, it protects the body from harmful invaders, which may be why it tends to help people with immune-related disorders.
  • LDN temporarily blocks pain-related receptors, causing the release of endorphins, the body's natural painkillers.

Use of Low-Dose Naltrexone

At very low doses, naltrexone can help people with fibromyalgia, chronic fatigue syndrome, and other conditions. Let's take a closer look at the benefits and uses of low-dose naltrexone.


Small studies have shown that people who received LDN to treat fibromyalgia experienced up to 30% reduction in symptoms compared to those who received dummy treatments.

Results tended to be better in those whose immune systems had an inflammatory response to the injury or disease. The drug was also well tolerated and produced few side effects.

LDN is not approved by the FDA for fibromyalgia, but may be prescribed for off-label use.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is also known as myalgic encephalomyelitis. This condition includes deep fatigue, non-refreshing sleep, exercise intolerance, and a neurological problem called "brain fog." Every person with chronic fatigue syndrome has a unique set of symptoms and degree of intensity.

LDN has not been studied in clinical trials for chronic fatigue syndrome, but it may be prescribed off the label; there is increasing evidence that some people have noticed a decrease in symptoms when using LDN.

Studies have shown that people with chronic fatigue syndrome may have ne, which is an inflammatory response to the brain or spinal cord. since LDN can affect inflammation to the nervous system, it is understood why it may be a useful treatment for some people. is understood.

Other Uses of Low-Dose Naltrexone

Studies have shown that low doses of naltrexone promise some results in the treatment of these other conditions.


Low doses of naltrexone are prescribed from signs as a treatment for fibromyalgia, chronic fatigue syndrome/myalgia encephalomyelitis, diabetic neuropathy, multiple sclerosis, Parkinson's disease and other conditions. However, there are limited studies that prove it to be effective.

What is the dosage of low-dose naltrexone?

For use in the treatment of fibromyalgia or chronic fatigue syndrome, naltrexone is generally administered in doses of 4.5 mg or less. It is usually started at 1.5 mg, going up to 3 mg, and then increased to 4.5 mg.

Keep in mind that the highest doses of naltrexone have not been shown to have the same effect as a reduction in symptoms of fibromyalgia or chronic fatigue syndrome.

Side Effects of LDN

Although LDN appears to be well tolerated, known side effects of naltrexone include dizziness, headache, difficulty sleeping (insomnia), severe dreams, nausea, vomiting, decreased appetite, joint pain, muscle cramps, and pain. If naltrexone is injected instead of taken as a pill, pain and edema may also occur at the injection site.

Rarely, there may be serious side effects, including increased blood pressure and heart rate, confusion, depression, and allergic reactions. If you experience any of them, contact your health care provider immediately.

People with kidney or liver disease may need to speak with a physician before starting LDN. People who are pregnant or breastfeeding should also speak with their physician before starting this medication.


Do not take naltrexone with certain medications or alcohol, even at low doses; do not take LDN with pain relievers such as Ultram (tramadol) or OxyContin (oxycodone).

Naltrexone can interact with chemotherapy drugs and the following drugs (known as CYP450 substrates)

  • Norvasc (Amlodipine)
  • Abilify (aripiprazole)
  • Lipitor (atorvastatin)
  • Buspar (Bouspirone)
  • Valium (Diazepam)
  • Erythrosine (erythromycin)
  • Proscar (finasteride)
  • Prometrium (progesterone)
  • Viagra (sildenafil)
  • Zocor (simvastatin)
  • Aveed (testosterone)
  • Coumadin (R-warfarin)


Researchers are not certain exactly how LDN functions in fibromyalgia and chronic fatigue syndrome. Some believe it can function as an anti-inflammatory factor, balance the immune system, or contribute to the release of endorphins.

In cases and cases of both, LDN has been shown to help minimize symptoms and minimize side effects of both fibromyalgia and chronic fatigue syndrome.

Words by the very well

If you are interested in trying LDN, talk to your health care provider about the potential benefits and drawbacks. Not all health care providers will prescribe LDN for people with fibromyalgia or chronic fatigue syndrome, as it is still considered a new treatment option.

Frequent question.

At higher doses, does naltrexone affect the body's systems differently?

Yes, it does. Research has shown that this drug appears safe for long-term use; if naltrexone benefits you, you can continue to take it.

Beywell Health uses only high quality sources, including reviewers, to support the events contained in the article. Read more about our annuity process and how we control the facts to keep your content accurate, reliable, and trustworthy.

Bolton MJ, Chapman BP, van Marwijk H. Low doses of naltrexone as treatment for chronic fatigue syndrome. bmj case officer 2020; 13(1):e232502. doi: 10. 1136/bcr-2019-232502

U.S. Food and Drug Administration. revia.

Substance and Mental Health Abuse Management. Naltrexone.

National Company for Multiple Sclerosis. Low Doses of Naltrexone.

National Alliance for Mental Illness. Naltrexone (Revia).

Memorial Sloan-Kettering Cancer Center. Low Doses of Naltrexone.

Ludwig MD, Turel AP, Zagon IS, McLaughlin PJ. long-term treatment with low-dose naltrexone maintains stable health in multiple sclerosis patients. Multiple Sclerosis Journal - Experimental, Translational, Clinical. 2016; 2: 205521731667224. doi: 10. 1177%2F2055217316672242

Adrienne Dellwo Adrienne Dellwo is an experienced journalist diagnosed with fibromyalgia and has written extensively on the subject.

Low Dose Naltrexone for Chronic Pain and Autoimmunity

Low-dose naltrexone (LDN) is currently being studied in patients with various types of chronic pain, including migraine, fibromyalgia, and neuropathy. Other conditions of chronic pain, various types of cancer, and autoimmune disorders are also being studied. These studies are ongoing, but are widely used in the United States for a variety of pain-related disorders and autoimmune conditions.

Studies indicate that low doses of naltrexone are safe.

Current research shows that low doses of naltrexone are a safe, cost-effective, and effective treatment for chronic pain and autoimmunity. lDN is known to cause inflammation and sensitize various tissues that may cause pain, a prominent chemical called a cytokine It is believed to work in the brain by reducing

By down regulating inflammation in the nervous system, it reduces pain and improves fatigue, sleep, mood, and physical function.

Differences between low and high doses of naltrexone

Low-dose naltrexone differs from high-dose naltrexone in that it is considered an FDA study. On the other hand, high-dose naltrexone (50 mg) has been approved by the FDA for many years to treat drug and alcohol abuse and deprivation.

Low-dose naltrexone is generic and cost-effective TX; LDN is currently available at regular pharmacies only in a 50 mg dose, so it really should be prepared at a special pharmacy.

High doses of naltrexone have treated various forms of addiction for many years, but there is now a stigma of addiction associated with the use of lower doses. The reported value of combined LDN is approximately $50 per month.

It is beneficial in the treatment of cancer and other conditions.

Low doses of naltrexone have also been proven in various studies on cancer to have the potential to affect immune system function by affecting gene expression. It has also been shown to be beneficial in the treatment of brain and nervous system disorders, including multiple sclerosis, ALS, and Parkinson's disease.

This prescription drug does not cause dependence. It should be used with caution in patients currently receiving opioids, including tramadol. It works by blocking opioid receptors throughout the body for 3-4-5 hours. To avoid drug interactions, opioid pain RX should be discontinued or reduced about a week before this drug is started. This is evaluated on an individual basis.

Initial dose is 0.5 to 1.0 mg at bedtime, gradually increasing to a target dose of 4.0 to 4.5 mg at bedtime. In the morning, start with 1.0 mg. Then, every 30 days, increase by 1.0 mg until relieved to a maximum dose of 4.0 mg at night. If taken at night, insomnia may occur.

Naltrexone Side EffectsSide effects of low doses of naltrexone are very rare. People may report having strong dreams in the first week or two of treatment. Very rare side effects include fatigue, stress, and dizziness. Side effects are much more common at the high doses used to treat addiction (more than 10 times the lowest dose) and are rarely observed at the typical low doses.

People with organ transplants or taking immunosuppressive medications may want to avoid LDN. In addition, people with Hashimoto's thyroiditis should use this drug cautiously, as thyroid supplements often need to be adapted early in treatment.